Yeah…kinda gonna have to disagree with Readers Digest there.
without paying attention to the present situation; despite the prevailing circumstances.
"they were determined to carry on regardless"
synonyms: anyway, anyhow, in any case, nevertheless, nonetheless, despite everything, in spite of everything, even so, all the same, in any event, come what may;
adjective & adverbinformal
If “irregardless” is a synonym for “regardless”, is “Irregular” a synonym of “regular”? No. it means “not regular”. The “Ir” modifies the root. So how can Irregardless and Regardless be synonyms, when Ir modifies “regardless” to mean “not regardless”?